17,048 research outputs found

    Development of rotorcraft interior. Noise control concepts. Phase 1: Definition study

    Get PDF
    A description of helicopter noise, diagnostic techniques for source and path identification, an interior noise prediction model, and a measurement program for model validation are provided

    Gene loss and lineage specific restriction-modification systems associated with niche differentiation in the Campylobacter jejuni Sequence Type 403 clonal complex

    Get PDF
    Campylobacter jejuni is a highly diverse species of bacteria commonly associated with infectious intestinal disease of humans and zoonotic carriage in poultry, cattle, pigs, and other animals. The species contains a large number of distinct clonal complexes that vary from host generalist lineages commonly found in poultry, livestock, and human disease cases to host-adapted specialized lineages primarily associated with livestock or poultry. Here, we present novel data on the ST403 clonal complex of C. jejuni, a lineage that has not been reported in avian hosts. Our data show that the lineage exhibits a distinctive pattern of intralineage recombination that is accompanied by the presence of lineage-specific restriction-modification systems. Furthermore, we show that the ST403 complex has undergone gene decay at a number of loci. Our data provide a putative link between the lack of association with avian hosts of C. jejuni ST403 and both gene gain and gene loss through nonsense mutations in coding sequences of genes, resulting in pseudogene formation

    A potential role for NEDD1 and the centrosome in senescence of mouse embryonic fibroblasts

    Get PDF
    Mouse embryonic fibroblasts (MEFs) are commonly grown in cell culture and are known to enter senescence after a low number of passages as a result of oxidative stress. Oxidative stress has also been suggested to promote centrosome disruption; however, the contribution of this organelle to senescence is poorly understood. Therefore, this study aimed to assess the role of the centrosome in oxidative stress induced-senescence using MEFs as a model. We demonstrate here that coincident with the entry of late-passage MEFs into senescence, there was an increase in supernumerary centrosomes, most likely due to centrosome fragmentation. In addition, disrupting the centrosome in early-passage MEFs by depletion of neural precursor cell expressed developmentally downregulated gene 1 (NEDD1) also resulted in centrosomal fragmentation and subsequent premature entry into senescence. These data show that a loss of centrosomal integrity may contribute to the entry of MEFs into senescence in culture, and that centrosomal disruption can cause senescence

    Photon collection from a trapped ion--cavity system

    Full text link
    We present the design and implementation of a trapped ion cavity QED system. A single ytterbium ion is confined by a micron-scale ion trap inside a 2 mm optical cavity. The ion is coherently pumped by near resonant laser light while the cavity output is monitored as a function of pump intensity and cavity detuning. We observe a Purcell enhancement of scattered light into the solid angle subtended by the optical cavity, as well as a three-peak structure arising from strongly driving the atom. This system can be integrated into existing atom{photon quantum network protocols and is a pathway towards an efficient atom{photon quantum interface

    Sofic-Dyck shifts

    Full text link
    We define the class of sofic-Dyck shifts which extends the class of Markov-Dyck shifts introduced by Inoue, Krieger and Matsumoto. Sofic-Dyck shifts are shifts of sequences whose finite factors form unambiguous context-free languages. We show that they correspond exactly to the class of shifts of sequences whose sets of factors are visibly pushdown languages. We give an expression of the zeta function of a sofic-Dyck shift

    Measurement of correlations between low-frequency vibrational modes and particle rearrangements in quasi-two-dimensional colloidal glasses

    Get PDF
    We investigate correlations between low-frequency vibrational modes and rearrangements in two-dimensional colloidal glasses composed of thermosensitive microgel particles which readily permit variation of sample packing fraction. At each packing fraction, the particle displacement covariance matrix is measured and used to extract the vibrational spectrum of the "shadow" colloidal glass (i.e., the particle network with the same geometry and interactions as the sample colloid but absent damping). Rearrangements are induced by successive, small reductions in packing fraction. The experimental results suggest that low-frequency quasi-localized phonon modes in colloidal glasses, i.e., modes that present low energy barriers for system rearrangements, are spatially correlated with rearrangements in this thermal system

    Counterions at Charged Cylinders: Criticality and universality beyond mean-field

    Full text link
    The counterion-condensation transition at charged cylinders is studied using Monte-Carlo simulation methods. Employing logarithmically rescaled radial coordinates, large system sizes are tractable and the critical behavior is determined by a combined finite-size and finite-ion-number analysis. Critical counterion localization exponents are introduced and found to be in accord with mean-field theory both in 2 and 3 dimensions. In 3D the heat capacity shows a universal jump at the transition, while in 2D, it consists of discrete peaks where single counterions successively condense.Comment: 4 pages, 3 figures; submitted to Phys. Rev. Lett. (2005
    • …
    corecore